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š¦· Floss vaccine beats flu
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Anthony Ao
July 30, 2025
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Scientists Vaccinate Mice via Flossing ā And It Works!
Published in Nature Biomedical Engineering on JulyāÆ22,āÆ2025, researchers tested a flu vaccine delivered by dental floss.
They coated floss with inactivated influenza virus and inserted it into the junctional epitheliumāthe permeable tissue where the tooth meets the gumāin mice.
Mice that received three flossings were later challenged with active flu virus; all vaccinated animals survived while all unvaccinated controls died. The flossābased immunization generated robust systemic and mucosal immunity, producing antibodies and immune cells in saliva and feces.
The team even used dyeācoated floss in human volunteers to confirm that compounds can reach the same gum tissue. The approach could enable painless, mailādeliverable vaccines for outbreaks and resourceālimited settings.
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In the study, 50 mice received three floss-based vaccinations every two weeks over a month; later they were exposed to live flu virus. All vaccinated mice survived, whereas the unvaccinated group succumbed.
The researchers targeted the junctional epithelium (JE) ā the permeable gumātooth junction ā to allow vaccine molecules to enter immuneārich tissues. The floss method induced both systemic immunity (antibodies in blood) and mucosal immunity (in saliva, feces, lungs, spleen, bone marrow), exceeding what traditional intramuscular shots usually achieve
A human feasibility test using floss picks coated with dye showed about 60% absorption into the JE, indicating potential human applicability; many volunteers reported theyād prefer this method over a needle.
Read full article here.
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